The concept of the gene has been the central organizing theme of 20th century biology. Biology has become increasingly influential both for philosophers seeking a naturalized basis for epistemology, ethics, and the understanding of the mind, as well as for the human sciences generally. The central task of this work is to get the story right about genes and in so doing provide a critical and enabling resourse for use in the further pursuit of human self-understanding. ;The work begins with (...) a wide-ranging historical reconstruction and conceptual analysis of the meaning of "the gene" that results in defining and distinguishing two different "genes". Each of these can be seen as an heir to one of the two major historical trends in explaining the source of biological order---preformationism and epigenesis. The preformationist gene predicts phenotypes but only on an instrumental basis where immediate medical and/or economic benefits can be had. The gene of epigenesis , by contrast, is a developmental resource that provides templates for RNA and protein synthesis but has in itself no determinate relationship to organismal phenotypes. The seemingly prevalent idea that genes constitute information for traits is based, I argue, upon an unwarranted conflation of these two senses which is in effect held together by rhetorical glue. Beyond this historical, conceptual, and rhetorical inquiry the bulk of the dissertation then concerns itself with an empirically up-to-date analysis of the cell and molecular basis of biological order and of the pathological loss of same. In each of these chapters I structure my analysis with the idea in mind that the "conflated" view can be held empirically accountable. Major touchpoints in this work include the ideas of I. Kant, J. Blumenbach, K. E. von Baer, J. Muller, R. Virchow, W. Johannsen, R. Falk, J. Sapp, E. Schrodinger, M. Delbruick, G. Gamow, R. Doyle, L. Kay, S. Kauffman, E. Jablonka, J. Rothman, K. Yamamoto, P. Rous, H. Temin, J. M. Bishop, H. Harris, E. Stanbridge, D. L. Smithers, B. Vogelstein, E. Farber and H. Rubin. (shrink)

Vaccinia virus, the world's oldest vaccine, was used originally for the eradication of smallpox. It is now being genetically engineered to create new live vaccines for use against other infectious agents of medical and veterinary importance. Genes coding for antigens of several pathogens have been linked to vaccinia virus transcriptional regulatory signals and inserted into the vaccinia virus genome. The resultant recombinant viruses are infectious, express the foreign gene, stimulate specific immune responses in vaccinated animals and can protect against disease (...) caused by the corresponding pathogen. (shrink)

Even a decade after the end of the 1914–1918 war, economic theory assumed that the world was tranquil and orderly. By 1939 an economic slump without parallel, allied to the re-emergence of military ambition in Europe, had brought economic theorists face to face with reality. In this classic book, first published in 1967, Professor Shackle provides a study, in exact and professional language, of the precise nature, structure, presuppositions, language and inter-relations of the theories which were formulated in these fourteen (...) years - unparalleled in the whole history of economics except perhaps by the years of the Physiocrats and Adam Smith. These theories are not prototypes on the way to something better but are of essential and permanent importance. (shrink)

Professor Pandit, working among the admirable group of philosophers at the University of Delhi, has written a fundamental criticism and a constructive re-interpretation of all that has been preserved as serious epistemological and methodological reflections on the sciences in modern Western philosoph- from the times of Galileo, Newton, Descartes and Leibniz to those of Russell and Wittgenstein, Carnap and Popper, and, we need hardly add, onward to the troubling relativisms and reconstructions of historical epistemologies in the works of Hanson, Kuhn, (...) Lakatos and Feyerabend. His themes are intrigu ing, set forth as they are with masterly case studies of physics and the life sciences, and within an original conceptual framework for philosophical analysis of the processes, functions, and structures of scientific knowing. Pandit's contributions deserve thoughtful examination. For our part, we wish to point to some among them: (1) an interactive articulation of subjective and objective factors of both problems and theories in the course of scientific development; (2) a striking contrast between the explanatory power of a scientific theory and its 'resolving power', i. e. (shrink)

A highly original reading of Immanuel Kant that demonstrates his interest in the social realm of human interaction.

Una importante causa filosófica e ideológica de la inhumanidad de la sociedad rusa durante las décadas del marxismo-leninismo fue la obsesiva orientación de los marxistas-leninistas hacia el futuro histórico (futuro comunismo) en aras de lo cual, comunidades, culturas y personas podían ser reducidas a medios para alcanzar ese fin histórico. El autor de los debates apoyándose en los propios pensadores rusos de la "tradición clásica", como por ejemplo Herzen, Dostoievsky, Tolstoy, Leontiev y Berdiaev. No se opone a cualquier tipo de (...) orientación de futuro, pero recalca la importancia de las personas actuales. (shrink)

In Philip of Macedon , as part of a general survey of the development of the art of war in Classical Greece, I briefly adumbrated a view of the nature of hoplite fighting. It was not the conventional one, of which the following statement of Adcock in The Greek and Macedonian Art of War p. 4 is fairly representative: The effectiveness of the phalanx depends in part on skill in fighting by those in the front rank, and in part on (...) thephysical and moral support of the lines behind them. The two opposing phalanxes meet each otherwith clash of shield on shield and blow of spear against spear. Their momentum is increased by the impetus of the charge that precedes their meeting. If the first clash is not decisive by the superior weight and thrust of the one phalanx over the other, the fighting goes on. The laterranks supply fighters as those before them fall. At last one side gains the upper hand. Then the other phalanx breaks and takes to flight and the battle is won and lost. (shrink)